Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK.

ABSTRACT:

Introduction

Cytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptional profile. Evidence from immune checkpoint blockade therapy supports that reversing T cell exhaustion is a promising strategy in cancer treatment. Ibrutinib, is a potent inhibitor of BTK, which has been approved for the treatment of chronic lymphocytic leukemia. Previous studies have reported improved function of T cells in ibrutinib long-term treated patients but the mechanism remains unclear. We investigated whether ibrutinib directly acts on CD8+ T cells and reinvigorates exhausted CTLs.

Methods

We used an established in v

SUBMITTER: Li L 

PROVIDER: S-EPMC10523025 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature