Efficacy of a Red-Light Controllable Nitric Oxide Releaser for Neurogenic Erectile Dysfunction: A Study Using a Rat Model of Cavernous Nerve Injury.

ABSTRACT:

Purpose

Neurogenic erectile dysfunction (ED) is a common side effect of radical prostatectomy (RP) because of cavernous nerve damage. In these patients, the production of nitric oxide (NO), which is important for erection, is decreased in the corpus cavernosum. Therefore, NO donors are useful for post-RP ED. However, short half-life and systemic side effects are problems of NO application in ED therapy. To avert these problems, we developed a red-light controllable NO releaser, NORD-1. This study aimed to investigate the effect of NORD-1 and red-light irradiation on neurogenic ED using a rat model of bilateral cavernous nerve injury (BCNI).

Materials and methods

BCNI and sham operations were conducted on 8-week-old rats. After 4 weeks, erectile function was evaluated using c

SUBMITTER: Mori T 

PROVIDER: S-EPMC10523118 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature