SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.

ABSTRACT:

Importance

The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.

Objective

To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.

Design, setting, and participants

Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.

Exposure

SARS-CoV-2 infection i

SUBMITTER: Lugar M 

PROVIDER: S-EPMC10523173 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature