Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice.

ABSTRACT:

Objective

An environmental context, which reliably predicts food availability, can increase the appetitive food drive within the same environment context. However, hunger is required for the development of such a context-induced feeding (CIF) response, suggesting the neural circuits sensitive to hunger link an internal energy state with a particular environment context. Since Agouti related peptide (AgRP) neurons are activated by energy deficit, we hypothesised that AgRP neurons are both necessary and sufficient to drive CIF.

Methods

To examine the role of AgRP neurons in the CIF process, we used fibre photometry with GCaMP7f, chemogenetic activation of AgRP neurons, as well as optogenetic control of AgRP neurons to facilitate acute temporal control not permitted with chemog

SUBMITTER: Reed F 

PROVIDER: S-EPMC10523265 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature