Association between recently raised anticholinergic burden and risk of acute cardiovascular events: nationwide case-case-time-control study.

ABSTRACT:

Objective

To evaluate the association between recently raised anticholinergic burden and risk of acute cardiovascular events in older adults.

Design

Case-case-time-control study (ie, incorporating a case crossover design and a control crossover design consisting of future cases).

Setting

Taiwan's National Health Insurance Research Database.

Participants

317 446 adults aged ≥65 who were admitted to hospital because of an incident acute cardiovascular event between 2011 and 2018. Acute cardiovascular events included myocardial infarction, strokes, arrhythmias, conduction disorders, and cardiovascular death.

Main outcome measures

The anticholinergic burden was measured for each participant by adding up the anticholinergic scores for individual drugs using t

SUBMITTER: Huang WC 

PROVIDER: S-EPMC10523277 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature