Altered intestinal barrier contributes to cognitive impairment in old mice with constipation after sevoflurane anesthesia.

ABSTRACT:

Background

Elderly patients have a high risk of developing postoperative cognitive dysfunction (POCD). Gastrointestinal disorders, such as constipation, in the elderly population may be involved in the pathogenesis of neurological disorders by promoting inflammatory responses due to a 'leaky gut'. General anesthetic sevoflurane may impair gastrointestinal function in elderly patients to trigger neurological complications following surgery. Therefore, we hypothesized that elderly individuals with gastrointestinal dysfunction may be more vulnerable to sevoflurane and consequently develop POCD.

Methods

Aged mice were randomly divided into four groups: control (CTRL), CTRL+sevoflurane (Sev), slow transit constipation (STC), and STC + Sev. Mice in the STC and STC + Sev groups wer

SUBMITTER: Zhao T 

PROVIDER: S-EPMC10523324 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature