Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.

ABSTRACT: Osteosarcoma (OS) is the most common primary malignant bone cancer in children and adolescents. While numerous other cancers now have promising therapeutic advances, treatment options for OS have remained unchanged since the advent of standard chemotherapeutics and offer less than a 25% 5-y survival rate for those with metastatic disease. This dearth of clinical progress underscores a lack of understanding of OS progression and necessitates the study of this disease in an innovative system. Here, we adapt a previously described engineered bone marrow (eBM) construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect OS tumor progression. We form eBM by implanting acellular bone-forming materials in mice and explanting the cellularized construc

SUBMITTER: Griffin KH 

PROVIDER: S-EPMC10523456 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature