Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage.

ABSTRACT: Multidrug-resistant bacteria are one of the most serious threats to infection control. Few new antibiotics have been developed; however, the lack of an effective new mechanism of their action has worsened the situation. Photodynamic inactivation (PDI) can break antimicrobial resistance, since it potentiates the effect of antibiotics, and induces oxidative stress in microorganisms through the interaction of light with a photosensitizer. This paper addresses the application of PDI for increasing bacterial susceptibility to antibiotics and helping in bacterial persistence and virulence. The effect of photodynamic action on resistant bacteria collected from patients and bacteria cells with induced resistance in the laboratory was investigated. Staphylococcus aureus resistance breakdown

SUBMITTER: Soares JM 

PROVIDER: S-EPMC10523486 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature