Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure.

ABSTRACT:

Background

The optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of many early neurodegenerative changes. In both humans and mice, astrocytes constitute the major glial cell type in the region, and in glaucoma they become reactive, influencing the optic nerve head (ONH) microenvironment and disease outcome. Despite recognizing their importance in the progression of the disease, the reactive response of optic nerve head astrocytes remains poorly understood.

Methods

To determine the global reactive response of ONH astrocytes in glaucoma we studied their transcriptional response to an elevation in IOP induced by the microbead occlusion model. To specifically isolate astrocyte mRNA in vivo from complex tissues, we use

SUBMITTER: Mazumder AG 

PROVIDER: S-EPMC10523752 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature