An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics.

ABSTRACT: Cardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the interplay of immunological and non-immunological factors, setting off a cascade of events promoting endothelial damage and vascular dysfunction. The etiology and evolution of tissue pathology are largely unknown, making disease management challenging. So far, in vivo models, mostly mouse-based, have been widely used to study CAV, but they are resource-consuming, pose many ethical issues, and allow limited investigation of time points and important biomechanical measurements. Recently, agent-based models (ABMs) proved to be valid computational tools for deciphering mechanobiological mechanisms driving vascu

SUBMITTER: Serafini E 

PROVIDER: S-EPMC10523786 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature