Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis.

ABSTRACT:

Background

Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture can seriously impede nerve function. Pyroptosis is an inflammatory mode of cell death whose underlying mechanisms involving the occurrence and rupture of IAs remain unclear. In this study, using bioinformatics analysis, we identified the potential pyroptosis-related genes (PRGs) and performed their inflammatory response mechanisms in IAs.

Methods

The mRNA expression matrix of the IA tissue was obtained from the Gene Expression Omnibus database, and 51 PRGs were obtained from previous articles collected from PubMed. The differentially expressed PRGs (DEPRGs) were performed using R software. Subsequently, we performed enrichment analysis, construc

SUBMITTER: Zhou D 

PROVIDER: S-EPMC10523789 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature