A Fracture Risk Assessment Tool for High Resolution Peripheral Quantitative Computed Tomography.

ABSTRACT: Most fracture risk assessment tools use clinical risk factors combined with bone mineral density (BMD) to improve assessment of osteoporosis; however, stratifying fracture risk remains challenging. This study developed a fracture risk assessment tool that uses information about volumetric bone density and three-dimensional structure, obtained using high-resolution peripheral quantitative compute tomography (HR-pQCT), to provide an alternative approach for patient-specific assessment of fracture risk. Using an international prospective cohort of older adults (n = 6802) we developed a tool to predict osteoporotic fracture risk, called μFRAC. The model was constructed using random survival forests, and input predictors included HR-pQCT parameters summarizing BMD and microarchitecture alongsid

SUBMITTER: Whittier DE 

PROVIDER: S-EPMC10523935 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature