APOE ε4 influences within and between network functional connectivity in posterior cortical atrophy and logopenic progressive aphasia.

ABSTRACT:

Introduction

Presence of apolipoprotein E (APOE) ε4 has shown greater predisposition to medial temporal involvement in posterior cortical atrophy (PCA) and logopenic progressive aphasia (LPA). Little is known about its influence on memory network connectivity, a network comprised of medial temporal structures.

Methods

Fifty-eight PCA and 82 LPA patients underwent structural and resting state functional magnetic resonance imaging (MRI). Bayesian hierarchical linear models assessed the influence of APOE ε4 on within and between-network connectivity for five networks.

Results

APOE ε4 carriers showed reduced memory and language within-network connectivity in LPA and increased salience within-network connectivity in PCA compared to non-carriers. Between-network analysis sh

SUBMITTER: Singh NA 

PROVIDER: S-EPMC10523970 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature