Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The association between adult body mass index (BMI) and lung cancer (LC) susceptibility have been reported, but the causal relationship with childhood BMI remains largely unclear. To evaluate the causal effect of childhood BMI on LC susceptibility, a two-sample Mendelian randomization (MR) study was performed.

Methods

The two-sample MR analysis utilized 25 single nucleotide polymorphisms (SNPs) as instrumental variables for childhood BMI. Genetic summary data from the International Lung Cancer Consortium and FinnGen databases were analyzed to estimate the causal effect of these SNPs on LC susceptibility. The IVW method was employed as the primary analysis, supplemented by the Weighted Median, MR-Egger, and MR pleiotropy residual sum and outlier test.

Results

SUBMITTER: Wu D 

PROVIDER: S-EPMC10523972 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature