Associations between prediagnostic aspirin use and ovarian tumor gene expression.

ABSTRACT:

Background

Aspirin use has been associated with reduced ovarian cancer risk, yet the underlying biological mechanisms are not fully understood. To gain mechanistic insights, we assessed the association between prediagnosis low and regular-dose aspirin use and gene expression profiles in ovarian tumors.

Methods

RNA sequencing was performed on high-grade serous, poorly differentiated, and high-grade endometrioid ovarian cancer tumors from the Nurses' Health Study (NHS), NHSII, and New England Case-Control Study (n = 92 cases for low, 153 cases for regular-dose aspirin). Linear regression identified differentially expressed genes associated with aspirin use, adjusted for birth decade and cohort. False discovery rates (FDR) were used to account for multiple testing and gene set

SUBMITTER: Sasamoto N 

PROVIDER: S-EPMC10523980 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature