Bubble-Based Microrobots with Rapid Circular Motions for Epithelial Pinning and Drug Delivery.

ABSTRACT: Remotely powered microrobots are proposed as next-generation vehicles for drug delivery. However, most microrobots swim with linear trajectories and lack the capacity to robustly adhere to soft tissues. This limits their ability to navigate complex biological environments and sustainably release drugs at target sites. In this work, bubble-based microrobots with complex geometries are shown to efficiently swim with non-linear trajectories in a mouse bladder, robustly pin to the epithelium, and slowly release therapeutic drugs. The asymmetric fins on the exterior bodies of the microrobots induce a rapid rotational component to their swimming motions of up to ≈150 body lengths per second. Due to their fast speeds and sharp fins, the microrobots can mechanically pin themselves to the bladder e

SUBMITTER: Lee JG 

PROVIDER: S-EPMC10524026 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature