Aging characteristics of colorectal cancer based on gut microbiota.

ABSTRACT:

Background

Aging is one of the factors leading to cancer. Gut microbiota is related to aging and colorectal cancer (CRC).

Methods

A total of 11 metagenomic data sets related to CRC were collected from the R package curated Metagenomic Data. After batch effect correction, healthy individuals and CRC samples were divided into three age groups. Ggplot2 and Microbiota Process packages were used for visual description of species composition and PCA in healthy individuals and CRC samples. LEfSe analysis was performed for species relative abundance data in healthy/CRC groups according to age. Spearman correlation coefficient of age-differentiated bacteria in healthy individuals and CRC samples was calculated separately. Finally, the age prediction model and CRC risk prediction mode

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10524056 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature