How do experts in psychiatric genetics view the clinical utility of polygenic risk scores for schizophrenia?

ABSTRACT: Polygenic risk scores (PRS) are promising for identifying common variant-related inheritance for psychiatric conditions but their integration into clinical practice depends on their clinical utility and psychiatrists' understanding of PRS. Our online survey explored these issues with 276 professionals working in psychiatric genetics (RR: 19%). Overall, participants demonstrated knowledge of how to interpret PRS results. Their performance on knowledge-based questions was positively correlated with participants' self-reported familiarity with PRS (r = 0.21, p = 0.0006) although differences were not statistically significant (Wald Chi-square = 3.29, df = 1, p = 0.07). However, only 48.9% of all participants answered all knowledge questions correctly. Many participants (56.5%), especially rese

SUBMITTER: Moorthy T 

PROVIDER: S-EPMC10524148 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature