V-Set Immunoglobulin Domain-Containing Protein 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity.

ABSTRACT:

Objective

To discover novel serum biomarkers that have diagnostic or predictive value in lupus nephritis (LN).

Methods

Using a quantitative protein microarray, we screened for high-abundant proteome expression in the serum of patients with LN compared to healthy controls. Top candidates from this screening were validated using a larger cohort of patients with LN compared to a disease control cohort (subjects with other chronic kidney diseases) and a healthy control cohort. Promising markers were then selected using a machine-learning model and further validated with a larger patient cohort. The corresponding autoantibodies and immune complexes containing these proteins were also examined.

Results

In total, 13 proteins were found to be significantly elevated in LN pati

SUBMITTER: Tang C 

PROVIDER: S-EPMC10524163 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature