Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells.

ABSTRACT: Novel approaches are required to improve the efficacy of immunotherapies and increase the proportion of patients who experience a benefit. Antibody-dependent cell-mediated cytotoxicity (ADCC) contributes to the efficacy of many monoclonal antibodies therapies. Natural killer (NK) cells mediate ADCC, though responses are highly variable and depend on prior treatment as well as other factors. Thus, strategies to increase NK cell activity are expected to improve multiple therapies. Both cytokine treatment and NK cell receptor engineering are being explored to increase ADCC. Post-translational modifications, including glycosylation, are widely recognized as mediators of cellular processes but minimally explored as an alternative strategy to increase ADCC. We evaluated the impact of treatment w

SUBMITTER: Rodriguez Benavente MC 

PROVIDER: S-EPMC10524233 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature