Association of Pregnancy and HIV Status With Molecular-Bacterial Vaginosis in Indian Women.

ABSTRACT:

Background

Bacterial vaginosis (BV) is a highly prevalent disorder of the cervicovaginal microbiota. Molecular-BV may put women at increased risk for adverse reproductive and obstetric outcomes. We investigated the association of HIV and pregnancy on the vaginal microbiota and associations with molecular-BV in women of reproductive age from Pune, India.

Setting

We studied vaginal samples from N = 170 women, including N = 44 nonpregnant HIV seronegative, N = 56 pregnant seronegative, N = 47 nonpregnant women with HIV (WWH), and N = 23 pregnant WWH, and collected data on clinical, behavioral, and demographic factors.

Methods

We used 16S rRNA gene amplicon sequencing to characterize the composition of the vaginal microbiota. We classified the vaginal microbiota of these

SUBMITTER: Tuddenham S 

PROVIDER: S-EPMC10524256 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature