Potentially inappropriate medication use is associated with increased risk of incident disability in healthy older adults.

ABSTRACT:

Background

Efforts to minimize medication risks among older adults include avoidance of potentially inappropriate medications (PIMs). However, most PIMs research has focused on older people in aged or inpatient care, creating an evidence gap for community-dwelling older adults. To address this gap, we investigated the impact of PIMs use in the ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial cohort.

Methods

Analysis included 19,114 community-dwelling ASPREE participants aged 70+ years (65+ if US minorities) without major cardiovascular disease, cognitive impairment, or significant physical disability. PIMs were defined according to a modified 2019 AGS Beers Criteria. Cox proportional-hazards regression models were used to estimate the association between bas

SUBMITTER: Lockery JE 

PROVIDER: S-EPMC10524300 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature