Autoantibodies against DNA topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses.

ABSTRACT: Antibodies reactive to self-antigens are an important component of posttransplant immune responses. The generation requirements and functions of autoantibodies, as well as the mechanisms of their influence on alloimmune responses, still remain to be determined. Our study investigated the contribution of autoimmunity during rejection of renal allografts. We have previously characterized a mouse model in which the acute rejection of a life-supporting kidney allograft is mediated by antibodies. At rejection, recipient sera screening against >4000 potential autoantigens revealed DNA topoisomerase I peptide 205-219 (TI-I_205-219) as the most prominent epitope. Subsequent analysis showed TI-I_205-219-reactive autoantibodies are induced in nonsensitized recipients of major his

SUBMITTER: Gorbacheva V 

PROVIDER: S-EPMC10524310 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature