Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis.

ABSTRACT:

Background

The circulating metabolome is altered in multiple sclerosis (MS), but its prognostic capabilities have not been extensively explored. Lipid metabolites might be of particular interest due to their multiple roles in the brain, as they can serve as structural components, energy sources, and bioactive molecules. Gaining a deeper understanding of the disease may be possible by examining the lipid metabolism in the periphery, which serves as the primary source of lipids for the brain.

Objective

To determine if altered serum lipid metabolites are associated with the risk of relapse and disability in children with MS.

Methods

We collected serum samples from 61 participants with pediatric-onset MS within 4 years of disease onset. Prospective longitudinal relapse da

SUBMITTER: Virupakshaiah A 

PROVIDER: S-EPMC10524330 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature