Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity From the Atopic Dermatitis Research Network (ADRN) Registry.

ABSTRACT:

Background

Atopic dermatitis (AD) is a chronic inflammatory skin condition with a highly variable clinical phenotype.

Objective

This study aimed to identify historical and clinical features and biomarkers associated with AD severity.

Methods

A US registry of extensively phenotyped AD participants (aged 0.73-80 years) were enrolled at 9 academic centers. Information on family and personal medical history, examination, skin swabs (culture), and serum biomarkers was collected to evaluate their association with AD severity.

Results

Participants with AD (N = 2862) whose disease was categorized as mild (11.6%), moderate (58.0%), or severe (30.4%) based on Rajka-Langeland scoring were enrolled. The trend test, when adjusting for gender, race, and age, demonstrated tha

SUBMITTER: Simpson EL 

PROVIDER: S-EPMC10524351 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature