Long-term Visit-to-Visit Variability in Hemoglobin A_1c and Kidney-Related Outcomes in Persons With Diabetes.

ABSTRACT:

Rationale & objective

To characterize associations between long-term visit-to-visit variability of hemoglobin A_1c (HbA_1c) and risk of adverse kidney outcomes in patients with diabetes.

Study design

Observational study.

Setting & participants

93,598 adults with diabetes undergoing routine care in Stockholm, Sweden.

Exposures and predictors

Categories of baseline and time-varying HbA_1c variability score (HVS, the percentage of total HbA_1c measures that vary by>0.5% [5.5mmol/mol] during a 3-year window): 0-20%, 21%-40%, 41%-60%, 61%-80%, and 81%-100%, with 0-20% as the reference group.

Outcome

Chronic kidney disease (CKD) progression (composite of>50% estimated glomerular filtration rate [eGFR] decline and kidney

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10524363 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature