X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease.

ABSTRACT:

Background

Sex differences in Parkinson's disease (PD) risk are well-known. However, the role of sex chromosomes in the development and progression of PD is still unclear.

Objective

The objective of this study was to perform the first X-chromosome-wide association study for PD risk in a Latin American cohort.

Methods

We used data from three admixed cohorts: (1) Latin American Research consortium on the Genetics of Parkinson's Disease (n = 1504) as discover cohort, and (2) Latino cohort from International Parkinson Disease Genomics Consortium (n = 155) and (3) Bambui Aging cohort (n = 1442) as replication cohorts. We also developed an X-chromosome framework specifically designed for admixed populations.

Results

We identified eight linkage disequilibrium regions

SUBMITTER: Leal TP 

PROVIDER: S-EPMC10524402 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature