Evaluation of Genetic and Nongenetic Risk Factors for Degenerative Cervical Myelopathy.

ABSTRACT:

Study design

Cohort study.

Objective

We aimed to evaluate the associations of genetic and nongenetic factors with degenerative cervical myelopathy (DCM).

Summary of background data

There is mounting evidence for an inherited predisposition for DCM, but uncertainty remains regarding specific genetic markers involved. Similarly, nongenetic factors are thought to play a role.

Materials and methods

Using diagnosis codes from hospital records linked to the UK Biobank cohort, patients with cervical spondylosis were identified followed by the identification of a subset with DCM. Nongenetic variables evaluated included age, sex, race, Townsend deprivation index, body mass index, occupational demands, osteoporosis, and smoking. Genome-wide association analyses were cond

SUBMITTER: Shlykov MA 

PROVIDER: S-EPMC10524420 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature