Outcomes of children with life-threatening status asthmaticus requiring isoflurane therapy and extracorporeal life support.

ABSTRACT:

Background

Severe, refractory asthma is a life-threatening emergency that may be treated with isoflurane and extracorporeal life support. The objective of this study was to describe the clinical response to isoflurane and outcomes after discharge of children who received isoflurane and/or extracorporeal life-support for near-fatal asthma.

Methods

This was a retrospective descriptive study using electronic medical record data from two pediatric intensive care units within a single healthcare system in Atlanta, GA.

Results

Forty-five children received isoflurane, and 14 children received extracorporeal life support, 9 without a trial of isoflurane. Hypercarbia and acidosis improved within four hours of starting isoflurane. Four children died during the index admission f

SUBMITTER: Kolli S 

PROVIDER: S-EPMC10524452 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature