Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ^Δ5 mice drives acute liver injury.

ABSTRACT:

Background

Hepatic deposition of cross-linked fibrin(ogen) occurs alongside platelet accumulation as a hallmark of acetaminophen (APAP)-induced liver injury.

Objectives

We sought to define the precise role of the fibrinogen γ-chain C-terminal integrin α_IIbβ₃ binding domain in APAP-induced liver injury.

Methods

Mice expressing mutant fibrinogen incapable of engaging integrin α_IIbβ₃ due to a C-terminal fibrinogen γ-chain truncation (mutant fibrinogen-γ^Δ5 [Fibγ^Δ5] mice) and wild-type mice were challenged with APAP (300 mg/kg, intraperitoneally).

Results

We observed an altered pattern of fibrin(ogen) deposition in the livers of APAP-challenged Fibγ^Δ5 mice. This led to the unexpected discov

SUBMITTER: Poole LG 

PROVIDER: S-EPMC10524487 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature