Misclassification Bias in the Assessment of Gene-by-Environment Interactions.

ABSTRACT:

Background

Misclassification bias is a common concern in epidemiologic studies. Despite strong bias on main effects, gene-environment interactions have been shown to be biased towards the null under gene-environment independence. In the context of a recent article examining the interaction between nerve agent exposure and paraoxonase-1 gene on Gulf War Illness, we aimed to assess the impact of recall bias-a common misclassfication bias-on the identification of gene-environment interactions when the independence assumption is violated.

Methods

We derive equations to quantify the bias of the interaction, and numerically illustrate these results by simulating a case-control study of 1000 cases and 1000 controls. Simulation input parameters included exposure prevalence, strength

SUBMITTER: Weisskopf MG 

PROVIDER: S-EPMC10524511 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature