Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.

ABSTRACT:

Introduction

Blood phosphorylated tau at threonine 217 (tau-PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau-PT217 remain largely unknown.

Methods

We investigated the effects of anesthesia/surgery on blood tau-PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium-like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests.

Results

Anesthesia/surgery induced acute increases in blood tau-PT217 via enhanced generation in the lungs and release from B cells. Tau-PT217 might cross the

SUBMITTER: Lu J 

PROVIDER: S-EPMC10524579 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature