Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness.

ABSTRACT: Through regulation of DNA packaging, histone proteins are fundamental to a wide array of biological processes. A variety of post-translational modifications (PTMs), including acetylation, constitute a proposed histone code that is interpreted by "reader" proteins to modulate chromatin structure. Canonical histones can be replaced with variant versions that add an additional layer of regulatory complexity. The protozoan parasite Toxoplasma gondii is unique among eukaryotes in possessing a novel variant of H2B designated H2B.Z. The combination of PTMs and the use of histone variants are important for gene regulation in T. gondii, offering new targets for drug development. In this work, T. gondii parasites were generated in which the 5 N-terminal acetylatable lysines in H2B.Z were mutated to

SUBMITTER: Vanagas L 

PROVIDER: S-EPMC10524646 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature