Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging.

ABSTRACT:

Objective

To evaluate in-vivo neuroinflammation and white matter (WM) microstructural integrity in occupational manganese (Mn) exposure.

Methods

We assessed brain inflammation using Diffusion Basis Spectrum Imaging (DBSI) in 26 Mn-exposed welders, 17 Mn-exposed workers, and 26 non-exposed participants. Cumulative Mn exposure was estimated from work histories and the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3) scores were completed by a movement specialist. Tract-based Spatial Statistics allowed for whole-brain voxel-wise WM analyses to compare WM DBSI-derived measures between the Mn-exposed and non-exposed groups. Exploratory grey matter region of interest (ROI) analyses examined the presence of similar alterations in the basal ganglia. We used voxel

SUBMITTER: Criswell SR 

PROVIDER: S-EPMC10524700 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature