Intravitreal Therapy for Uveitic Macular Edema-Ranibizumab versus Methotrexate versus the Dexamethasone Implant: The MERIT Trial Results.

ABSTRACT:

Purpose

To evaluate the effectiveness of 3 different intravitreal treatments for persistent or recurrent uveitic macular edema (ME): dexamethasone implant, methotrexate, and ranibizumab.

Design

Single-masked, randomized controlled clinical trial.

Participants

Patients with minimally active or inactive uveitis and persistent or recurrent uveitic ME in one or both eyes.

Methods

Patients at 33 centers were randomized 1:1:1 to receive 1 of the 3 therapies. Patients with bilateral ME received the same treatment in both eyes.

Main outcome measures

The primary outcome, measured at 12 weeks, was reduction in central subfield thickness (CST) expressed as a proportion of baseline (CST per CST at baseline) assessed with spectral-domain OCT by readers masked to trea

SUBMITTER: Multicenter Uveitis Steroid Treatment Trial (MUST) Research Group, Writing Committee: 

PROVIDER: S-EPMC10524707 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature