A novel ex vivo tracheobronchomalacia model for airway stent testing and in vivo model refinement.

ABSTRACT:

Objectives

We sought to develop an ex vivo trachea model capable of producing mild, moderate, and severe tracheobronchomalacia for optimizing airway stent design. We also aimed to determine the amount of cartilage resection required for achieving different tracheobronchomalacia grades that can be used in animal models.

Methods

We developed an ex vivo trachea test system that enabled video-based measurement of internal cross-sectional area as intratracheal pressure was cyclically varied for peak negative pressures of 20 to 80 cm H₂O. Fresh ovine tracheas were induced with tracheobronchomalacia by single mid-anterior incision (n = 4), mid-anterior circumferential cartilage resection of 25% (n = 4), and 50% per cartilage ring (n = 4) along an approximately 3-cm lengt

SUBMITTER: Mondal A 

PROVIDER: S-EPMC10524727 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature