Clinical value of serum miR-1-3p as a potential circulating biomarker for abdominal aortic aneurysm.

ABSTRACT:

Background

Although abdominal aortic aneurysm (AAA) is associated with life-threatening complications, there are still limited reliable biomarkers for diagnostic purpose. MicroRNAs (miRNAs) have been proposed as the potential diagnostic and risk stratification markers of AAA patients, and we aim to evaluate the serum level of miR-1-3p and its diagnostic value in AAA.

Methods

This study included 200 AAA patients and 200 controls. Demographic data and clinical information were collected from the subjects' medical records. Individual image analyses of AAA morphology were determined based on computed tomography angiography (CTA). The levels of serum miRNA expression were detected by quantitative real-time PCR. Bioinformatics tools were used to identify the target genes of miR-1-

SUBMITTER: Jing J 

PROVIDER: S-EPMC10524769 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature