Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study.

ABSTRACT:

Background

Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring.

Methods

For this cross-sectional study, we harmonized and pooled data for 17,194 older adults from nine population-based cohorts of eight countries. These studies conducted face-to-face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring.

Results

The mean age of the partici

SUBMITTER: Oh DJ 

PROVIDER: S-EPMC10524874 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature