Dimensionality reduction reveals separate translation and rotation populations in the zebrafish hindbrain.

ABSTRACT: In many brain areas, neuronal activity is associated with a variety of behavioral and environmental variables. In particular, neuronal responses in the zebrafish hindbrain relate to oculomotor and swimming variables as well as sensory information. However, the precise functional organization of the neurons has been difficult to unravel because neuronal responses are heterogeneous. Here, we used dimensionality reduction methods on neuronal population data to reveal the role of the hindbrain in visually driven oculomotor behavior and swimming. We imaged neuronal activity in zebrafish expressing GCaMP6s in the nucleus of almost all neurons while monitoring the behavioral response to gratings that rotated with different speeds. We then used reduced-rank regression, a method that condenses the

SUBMITTER: Feierstein CE 

PROVIDER: S-EPMC10524920 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature