Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.

ABSTRACT: Protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) is a transmembrane tyrosine phosphatase (TP) expressed in endothelial cells and required for stimulation of cell migration by vascular endothelial growth factor A₁₆₅ (VEGFA₁₆₅ ) and pleiotrophin (PTN). It is also over or under-expressed in various tumor types. In this study, we used genetically engineered Ptprz1^-/- and Ptprz1^+/+ mice to study mechanistic aspects of PTPRZ1 involvement in angiogenesis and investigate its role in lung adenocarcinoma (LUAD) growth. Ptprz1^-/- lung microvascular endothelial cells (LMVEC) have increased angiogenic features compared with Ptprz1^+/+ LMVEC, in line with the increased lung angiogenesis and the enhanced chemically induced LUAD growth

SUBMITTER: Kastana P 

PROVIDER: S-EPMC10524925 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature