Network Localization of Awareness in Visual and Motor Anosognosia.

ABSTRACT:

Objective

Unawareness of a deficit, anosognosia, can occur for visual or motor deficits and lends insight into awareness itself; however, lesions associated with anosognosia occur in many different brain locations.

Methods

We analyzed 267 lesion locations associated with either vision loss (with and without awareness) or weakness (with and without awareness). The network of brain regions connected to each lesion location was computed using resting-state functional connectivity from 1,000 healthy subjects. Both domain specific and cross-modal associations with awareness were identified.

Results

The domain-specific network for visual anosognosia demonstrated connectivity to visual association cortex and posterior cingulate while motor anosognosia was defined by insula,

SUBMITTER: Kletenik I 

PROVIDER: S-EPMC10524951 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature