T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn^-/- mice.

ABSTRACT: Systemic Lupus Erythematosus (SLE) is characterized by pathogenic autoantibodies against nucleic acid-containing antigens. Understanding which B-cell subsets give rise to these autoantibodies may reveal therapeutic approaches for SLE that spare protective responses. Mice lacking the tyrosine kinase Lyn, which limits B and myeloid cell activation, develop lupus-like autoimmune diseases characterized by increased autoreactive plasma cells (PCs). We used a fate-mapping strategy to determine the contribution of T-bet⁺ B cells, a subset thought to be pathogenic in lupus, to the accumulation of PCs and autoantibodies in Lyn^-/- mice. Approximately, 50% of splenic PCs in Lyn^-/- mice originated from T-bet⁺ cells, a significant increase compared to WT mice

SUBMITTER: Ottens K 

PROVIDER: S-EPMC10524956 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature