Real-World Driving Data Indexes Dopaminergic Treatment Effects in Parkinson's Disease.

ABSTRACT:

Background

Driving is a complex, everyday task that impacts patient agency, safety, mobility, social connections, and quality of life. Digital tools can provide comprehensive real-world (RW) data on driver behavior in patients with Parkinson's disease (PD), providing critical data on disease status and treatment efficacy in the patient's own environment.

Objective

This pilot study examined the use of driving data as a RW digital biomarker of PD symptom severity and dopaminergic therapy effectiveness.

Methods

Naturalistic driving data (3974 drives) were collected for 1 month from 30 idiopathic PD drivers treated with dopaminergic medications. Prescriptions data were used to calculate levodopa equivalent daily dose (LEDD). The association between LEDD and driver mobilit

SUBMITTER: Chang JH 

PROVIDER: S-EPMC10525064 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature