Potent Antioxidant and Anti-Tyrosinase Activity of Butein and Homobutein Probed by Molecular Kinetic and Mechanistic Studies.

ABSTRACT: Butein (BU) and homobutein (HB) are bioactive polyhydroxylated chalcones widespread in dietary plants, whose antioxidant properties require mechanistic definition. They were investigated by inhibited autoxidation kinetic studies of methyl linoleate in Triton™ X-100 micelles at pH 7.4, 37 °C. Butein had k_inh = (3.0 ± 0.9) × 10⁴ M^-1s^-1 showing a chain-breaking mechanism with higher antioxidant activity than reference α-tocopherol (k_inh = (2.2 ± 0.6) × 10⁴ M^-1s^-1), particularly concerning the stoichiometry or peroxyl radical trapping n = 3.7 ± 1.1 vs. 2.0 for tocopherol. Homobutein had k_inh = (2.8 ± 0.9) × 10³ M^-1s^-1, pairing the relat

SUBMITTER: Pan W 

PROVIDER: S-EPMC10525132 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature