Discriminative Identification of SARS-CoV-2 Variants Based on Mass-Spectrometry Analysis.

ABSTRACT: The spread of SARS-CoV-2 variants of concern (VOCs) is of great importance since genetic changes may increase transmissibility, disease severity and reduce vaccine effectiveness. Moreover, these changes may lead to failure of diagnostic measures. Therefore, variant-specific diagnostic methods are essential. To date, genetic sequencing is the gold-standard method to discriminate between variants. However, it is time-consuming (taking several days) and expensive. Therefore, the development of rapid diagnostic methods for SARS-CoV-2 in accordance with its genetic modification is of great importance. In this study we introduce a Mass Spectrometry (MS)-based methodology for the diagnosis of SARS-CoV-2 in propagated in cell-culture. This methodology enables the universal identification of SARS-C

SUBMITTER: Feldberg L 

PROVIDER: S-EPMC10525290 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature