The characteristics and alteration of peripheral immune function in patients with multiple system atrophy.

ABSTRACT:

Objective

Multiple system atrophy (MSA) is a degenerative disease. Immune dysfunction found to play a crucial role in the pathogenesis of this disease in the literature, while the characteristics of peripheral immune function remain unclear. This study aimed to investigate the characteristics and alterations of peripheral immune function in patients with MSA.

Methods

A case-control study was conducted between January 2021 to December 2022 at SanBo Brain Hospital, Capital Medical University, Beijing, China. A total of 74 participants were recruited, including 47 MSA patients and 27 non-MSA participants. Peripheral blood samples were collected from each participant. A total of 29 types of immune cells were measured using the flow cytometry analysis technology. Single-factor an

SUBMITTER: Wang M 

PROVIDER: S-EPMC10525398 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature