Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives not only of those who are diagnosed but also of their caregivers. Despite the enormous social, economic and political burden, AD remains a disease without an effective treatment and with several failed attempts to modify the disease course. The fact that AD clinical diagnosis is most often performed at a stage at which the underlying pathological events are in an advanced and conceivably irremediable state strongly hampers treatment attempts. This raises the awareness of the need to identify and characterize the early brain changes in AD, in order to identify possible novel therapeutic targets to circumvent AD's cascade of events. One of the most auspicious targets is mitochondria, powerful organelle

SUBMITTER: Sousa T 

PROVIDER: S-EPMC10525414 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature