Metformin Protects Rat Skeletal Muscle from Physical Exercise-Induced Injury.

ABSTRACT: Metformin (Met) is a drug commonly prescribed in type 2 diabetes mellitus. Its efficacy is due to the suppression of hepatic gluconeogenesis, enhancement of peripheral glucose uptake and lower glucose absorption by the intestine. Recent studies have reported Met efficacy in other clinical applications, such as age-related diseases. Despite the wide clinical use of Met, its mechanism of action on muscle and its effect on muscle performance are unclear. We investigated the effects of Met combined with training on physical performance (PP) in healthy rats receiving Met for 8 weeks while undergoing daily moderate exercise. We evaluated the following: PP through graded endurance exercise test performed before the beginning of the training protocol and 48 h before the end of the training period;

SUBMITTER: Abbadessa G 

PROVIDER: S-EPMC10525561 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature