Evaluation of the Antibacterial Effect of Aurone-Derived Triazoles on Staphylococcus aureus.

ABSTRACT: Infections caused by antibiotic-resistant bacteria continue to pose a significant public health threat despite their overall decreasing numbers in the last two decades. One group of compounds fundamental to the search for new agents is low-cost natural products. In this study, we explored a group of newly synthesized novel aurone-derived triazole compounds to identify those with pharmaceutical potential as inhibitors of antibiotic-resistant Staphylococcus aureus. Using the broth microdilution method, antibacterial activities against methicillin-resistant S. aureus ATCC 43300 (MRSA) and methicillin-sensitive S. aureus ATCC 29213 (MSSA) were identified for four aurone-derived triazole compounds, AT106, AT116, AT125, and AT137, using the half-maximal inhibitory concentrat

SUBMITTER: Szepe CK 

PROVIDER: S-EPMC10525585 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature