Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles.

ABSTRACT: Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous cellular functions such as tumor growth, metastasis, immunosuppression, and angiogenesis. They can be used as a drug delivery platform because they can protect drugs from degradation and target specific cells or tissues. With the advancement in the technologies and methods in EV research, EV-therapeutics are one of the fast-growing domains in the human health sector. Therapeutic translation of EVs in clinics requires assessing the quality, safety, and efficacy of the EVs, in which pharmacokinetics is very crucial. We report here the application of physiologically based pharmacokinetic (PBPK) modeling as a principal tool for the predictio

SUBMITTER: Kumar P 

PROVIDER: S-EPMC10525702 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature